Lymphocyte migration studies

Lymphocyte migration studies.

For maintenance of immunity and tolerance, the organs and tissues of the organism are connected by migrating lymphoid cells. Understanding lymphocyte migration is essential for many disorders and diseases-- especially in the mucosa-lined organs. Detailed analyses of migrating lymphocytes have been performed in many species, especially in laboratory animals. However, important experiments in lym...

Fluorescent dyes for lymphocyte migration and proliferation studies.

Fluorescent dyes are increasingly being exploited to track lymphocyte migration and proliferation. The present paper reviews the properties and performance of some 14 different fluorescent dyes that have been used during the last 20 years to monitor lymphocyte migration. Of the 14 dyes discussed, two stand out as being the most versatile in terms of long-term tracking of lymphocytes and their a...

Lymphocyte migration into atherosclerotic plaque.

Adaptive immunity is involved in the pathogenesis of atherosclerosis, but the recruitment of T and B lymphocytes to atherosclerotic lesions is not as well studied as that of monocytes. In this review, we summarize the current understanding of the role of lymphocyte subsets in the pathogenesis of atherosclerosis and discuss chemokines and chemokine receptors involved in lymphocyte homing to athe...

Lymphocyte Migration: A new spin on lymphocyte homing

New evidence confirms the multi-step model for leukocyte migration through endothelia, but with a twist. The selectins are not always required, and some lymphocyte subsets rely heavily on integrins for their migration to tissues.

Adhesion Molecules Controlling Lymphocyte Migration Minireview